Spotlight on protein N-terminal acetylation
نویسندگان
چکیده
منابع مشابه
Towards a Functional Understanding of Protein N-Terminal Acetylation
Protein N-terminal acetylation is a major modification of eukaryotic proteins. Its functional implications include regulation of protein-protein interactions and targeting to membranes, as demonstrated by studies of a handful of proteins. Fifty years after its discovery, a potential general function of the N-terminal acetyl group carried by thousands of unique proteins remains enigmatic. Howeve...
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Amino-terminal acetylation is probably the most common protein modification in eukaryotes with as many as 50%-80% of proteins reportedly altered in this way. Here we report a systematic analysis of the predicted N-terminal processing of cytosolic proteins versus those destined to be sorted to the secretory pathway. While cytosolic proteins were profoundly biased in favour of processing, we foun...
متن کاملA review of COFRADIC techniques targeting protein N-terminal acetylation
Acetylation of nascent protein Nalpha-termini is a common modification among archae and eukaryotes and can influence the structure and function of target proteins. This modification has been studied on an individual protein or (synthetic) peptide level or on a proteome scale using two-dimensional polyacrylamide gel electrophoresis. We recently developed mass spectrometry driven proteome analyti...
متن کاملProtein N-terminal acetylation is required for embryogenesis in Arabidopsis
Early embryonic development generates precursors of all major cell types in Arabidopsis. Among these precursors, the hypophysis divides asymmetrically to form the progenitors of the quiescent center and columella stem cells. A great deal has been learnt about the mechanisms that control the asymmetric division of the hypophysis and embryogenesis at the transcriptional level; however, no evidenc...
متن کاملProtein N-terminal acetylation: NAT 2007–2008 Symposia
Protein N-terminal acetylation is a very common modification, but has during the past decades received relatively little attention. In order to put this neglected field back on the scientific map, we have in May 2007 and September 2008 arranged two international NAT symposia in Bergen, Norway. This supplement contains selected proceedings from these symposia reflecting the current status of the...
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ژورنال
عنوان ژورنال: Experimental & Molecular Medicine
سال: 2018
ISSN: 1226-3613,2092-6413
DOI: 10.1038/s12276-018-0116-z